It tells the story of Amélie Poulain, played by Audrey Tautou, a shy and quirky waitress who decides to change the lives of those around her for the better while dealing with her own isolation. The film features an ensemble cast of supporting roles, including Mathieu Kassovitz, Rufus, Lorella Cravotta, Serge Merlin, Jamel Debbouze, Claire Maurier, Clotilde Mollet, Isabelle Nanty, Dominique Pinon, Artus de Penguern, Yolande Moreau, Urbain Cancelier, and Maurice Bénichou.